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The glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and now next-generation multi-agonists that include GLP-1 activity, are producing average weight reductions far larger than previously expected from drugs, reshaping clinical practice and how clinicians and patients think about obesity treatment

Finally, remember that volatility and hit frequency are not value judgments but styles

More research is needed to understand these complex relationships

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